H.Pylori-Eradication Reduces Tissue Content Of Hepatocyte Growth Factor (Hgf) In The Antral Mucosa With Intestinal Metaplasia

pylon on TGF-c~ release, we next examined CM from MKN-28 cells cocuhured with H. pylorL In cot~,tnlst, TGF-r was hmnd in the CM from cocuhure cells in the absence of PMA.Furthermore, TGFqa was also found in CM obtained from gastnc biopsy speciniens without PMA treatment.TGF-~* levels in the CM were correlated with scm~s {or activity and inflammation ot gastrius and the presence ot H. pylori.Conclusion: H pylon, but not IU113, might induce ectodomain shedding of TGF-~x in gastric epithelial cells.