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Discovery of a vorapaxar analog with increased aqueous solubility.

Yan Xia,Samuel Chackalamannil,William J Greenlee,Yuguang Wang,Zhiyong Hu,Yuriko Root,Jesse Wong,Jianshe Kong,Ho-Sam Ahn,George Boykow,Yunsheng Hsieh,Stan Kurowski,Madhu Chintala

Bioorganic & Medicinal Chemistry Letters（2010）

Cited 21|Views54
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Abstract
An analog of the thrombin receptor antagonist vorapaxar (SCH 530348) with increased aqueous solubility, compound 9c (SCH 602539), was discovered through incorporation of polar substituents on the pyridine ring of the himbacine-derived lead series.
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Key words
Thrombin receptor antagonist,PAR-1 antagonist,Solubility,Vorapaxar analog,SCH 530348 analog,SCH 602539
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