Primary Lesion Fdg Uptake Is Correlated With Clinical Stage For Adenocarcinoma But Not Squamous Cell Carcinoma In Lung Cancer Patients

Purpose/Objective(s)TNM stage is the most significant prognostic factor for non-small cell lung cancer (NSCLC). A growing number of retrospective studies demonstrate that the intensity of FDG uptake of the primary tumor is highly correlated with survival. But there is few data on the relationship between FDG uptake and clinical stage for NSCLC.Materials/MethodsFrom December 2003 to November 2007, the patients who were proven or suspected to be lung cancer and conducted FDG PET/CT staging in the nuclear medicine center of Shandong Cancer Hospital were reviewed. Only having a definite histologic or cytologic evidence to be adenocarcinoma(AC) or squamous cell carcinoma(SCC) patients were analyzed. The FDG uptake was quantified as the maximum standardized uptake value (SUVmax). The primary tumor size was determined by greatest dimension on the mediastinal windows of the chest CT. Staging was performed according to the 1997 international staging system The SUVmax and tumor size were compared between AC and SCC group. The SUVmax was analyzed among different stage and the correlation between SUVmax and tumor size or clinical stage was also analyzed.ResultsTwo hundred and sixty-six cases (194 men and 72 women; age range 31y-90y, median 62y).were analyzed, which included 161 AC and 105 SCC patients. The T-N-M status was established for all subjects, including stage I, 58 cases; II, 35 cases; III, 64 cases; and IV, 109 cases. Both size (3.23±1.68cm Vs 2.63±1.33cm, p = 0.004) and SUVmax (9.82±5.08 Vs 8.43±4.21, p = 0.016)were significantly higher for SCC compared to AC patients. There was positive correlation between the SUVmax and size for both SCC and AC (pearson: r = 0.651, 0.632, respectively; both p = 0.000). Significant difference is found among different stages in SUVmax for AC (F = 11.693, p = 0.000) but not for SCC (F = 1.514, p = 0.216). A significant correlation was found between tumor stage and FDG uptake value for AC (r = 0.403, p = 0.000), but not for SCC (r = 0.160, p = 0.103).ConclusionsTumor size and histologic subtype have influence upon FDG uptake in non small cell lung cancer. It demonstrates significant correlation between clinical stage and SUVmax for AC, but not for SCC. Purpose/Objective(s)TNM stage is the most significant prognostic factor for non-small cell lung cancer (NSCLC). A growing number of retrospective studies demonstrate that the intensity of FDG uptake of the primary tumor is highly correlated with survival. But there is few data on the relationship between FDG uptake and clinical stage for NSCLC. TNM stage is the most significant prognostic factor for non-small cell lung cancer (NSCLC). A growing number of retrospective studies demonstrate that the intensity of FDG uptake of the primary tumor is highly correlated with survival. But there is few data on the relationship between FDG uptake and clinical stage for NSCLC. Materials/MethodsFrom December 2003 to November 2007, the patients who were proven or suspected to be lung cancer and conducted FDG PET/CT staging in the nuclear medicine center of Shandong Cancer Hospital were reviewed. Only having a definite histologic or cytologic evidence to be adenocarcinoma(AC) or squamous cell carcinoma(SCC) patients were analyzed. The FDG uptake was quantified as the maximum standardized uptake value (SUVmax). The primary tumor size was determined by greatest dimension on the mediastinal windows of the chest CT. Staging was performed according to the 1997 international staging system The SUVmax and tumor size were compared between AC and SCC group. The SUVmax was analyzed among different stage and the correlation between SUVmax and tumor size or clinical stage was also analyzed. From December 2003 to November 2007, the patients who were proven or suspected to be lung cancer and conducted FDG PET/CT staging in the nuclear medicine center of Shandong Cancer Hospital were reviewed. Only having a definite histologic or cytologic evidence to be adenocarcinoma(AC) or squamous cell carcinoma(SCC) patients were analyzed. The FDG uptake was quantified as the maximum standardized uptake value (SUVmax). The primary tumor size was determined by greatest dimension on the mediastinal windows of the chest CT. Staging was performed according to the 1997 international staging system The SUVmax and tumor size were compared between AC and SCC group. The SUVmax was analyzed among different stage and the correlation between SUVmax and tumor size or clinical stage was also analyzed. ResultsTwo hundred and sixty-six cases (194 men and 72 women; age range 31y-90y, median 62y).were analyzed, which included 161 AC and 105 SCC patients. The T-N-M status was established for all subjects, including stage I, 58 cases; II, 35 cases; III, 64 cases; and IV, 109 cases. Both size (3.23±1.68cm Vs 2.63±1.33cm, p = 0.004) and SUVmax (9.82±5.08 Vs 8.43±4.21, p = 0.016)were significantly higher for SCC compared to AC patients. There was positive correlation between the SUVmax and size for both SCC and AC (pearson: r = 0.651, 0.632, respectively; both p = 0.000). Significant difference is found among different stages in SUVmax for AC (F = 11.693, p = 0.000) but not for SCC (F = 1.514, p = 0.216). A significant correlation was found between tumor stage and FDG uptake value for AC (r = 0.403, p = 0.000), but not for SCC (r = 0.160, p = 0.103). Two hundred and sixty-six cases (194 men and 72 women; age range 31y-90y, median 62y).were analyzed, which included 161 AC and 105 SCC patients. The T-N-M status was established for all subjects, including stage I, 58 cases; II, 35 cases; III, 64 cases; and IV, 109 cases. Both size (3.23±1.68cm Vs 2.63±1.33cm, p = 0.004) and SUVmax (9.82±5.08 Vs 8.43±4.21, p = 0.016)were significantly higher for SCC compared to AC patients. There was positive correlation between the SUVmax and size for both SCC and AC (pearson: r = 0.651, 0.632, respectively; both p = 0.000). Significant difference is found among different stages in SUVmax for AC (F = 11.693, p = 0.000) but not for SCC (F = 1.514, p = 0.216). A significant correlation was found between tumor stage and FDG uptake value for AC (r = 0.403, p = 0.000), but not for SCC (r = 0.160, p = 0.103). ConclusionsTumor size and histologic subtype have influence upon FDG uptake in non small cell lung cancer. It demonstrates significant correlation between clinical stage and SUVmax for AC, but not for SCC. Tumor size and histologic subtype have influence upon FDG uptake in non small cell lung cancer. It demonstrates significant correlation between clinical stage and SUVmax for AC, but not for SCC.