P33.01: Coexistent cytomegalovirus and toxoplasma gondii infection in a pregnant women: Prenatal Diagnosis and pathologic correlation

We report a case of coexistent Cytomegalovirus and Toxoplasma Gondii infection during pregnancy. A 28 years old-woman, G4P2A1, was referred to our unit because of these ultrasound findings. Ultrasound examination demonstrated a gestational age of 27 weeks, ventriculomegaly and fetal ascites. There is a significant antecedent history of a positive serologic test for cytomegalovirus infection, and a non studied virosis three months before. A follow-up ultrasound reports hydrocephalus, Dandy Walker Variant, congenital cactaract, hidrothorax, ascites, and hepatic calcifications, suggesting fetal infection or aneuploidy. Placental and Fetal Doppler at 33 weeks demonstrated the absence of end-diastolic flow in umbilical artery, and the presence of anhydramnios, then a cesarean section is performed to immediate termination of pregnancy. A female newborn is obtained, weighing 1950 g, and 41 cm in length, an APGAR score of 4-3-3, and a physical examination that shows microcephaly, and hepatosplenomegaly, diying a few hours after birth. Anatomical and histologic-pathologic report evidentiates coexistent Cytomegalovirus and Toxoplasma Gondii infection that is a rare form of coinfection in pregancy women.