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An Efficient Multigram Synthesis of Monomers for the Preparation of Novel Oligonucleotides Containing Isosteric Non-Phosphorous Backbones

Stuart Dimock,Balkrishen Bhat,Didier Peoc'h,Yogesh Sanghvi,Eric Swayze

NUCLEOSIDES & NUCLEOTIDES（1997）

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Abstract
The facile preparation of two novel classes of nucleoside analogs for the inclusion as dimeric non-phosphorous containing subunits in chimeric backbones has been accomplished. The concise preparation of 3'-formylnucleosides and 5'-O-(N-methylhydroxylamino)-nucleosides is reported.
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Key words
novel oligonucleotides,efficient multigram synthesis,monomers,non-phosphorous
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