Synthetic Route Optimization Of Pf-00868554, An Hcv Polymerase Inhibitor In Clinical Evaluation
SYNLETT(2010)
摘要
This paper describes the optimization efforts to establish an enabling synthesis to provide multigram quantity of PF-00868554, an HCV polymerase inhibitor currently in phase II clinical evaluations.
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关键词
HCV polymerase inhibitor,Heck reaction,dihydropyrone,pyridine synthesis,borane pyridine
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