Synthetic Route Optimization Of Pf-00868554, An Hcv Polymerase Inhibitor In Clinical Evaluation

Sarah Johnson,Matt Drowns,John Tatlock,Angelica Linton,Javier Gonzalez,Robert Hoffman,Tanya Jewell,Leena Patel,Julie Blazel,Mingnam Tang,Hui Li

SYNLETT（2010）

引用 9|浏览26

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摘要

This paper describes the optimization efforts to establish an enabling synthesis to provide multigram quantity of PF-00868554, an HCV polymerase inhibitor currently in phase II clinical evaluations.

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关键词

HCV polymerase inhibitor,Heck reaction,dihydropyrone,pyridine synthesis,borane pyridine

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