火把花根片对EAE大鼠脑和脊髓L-选择素表达的影响
Chinese Archives of Traditional Chinese Medicine(2011)
Abstract
目的:探讨火把化根片对实验性自身免疫性脑脊髓炎(EAE)大鼠的治疗作用及L-选择素的影响。方法:模型组采用豚鼠髓鞘蛋白匀浆和福氏完全佐剂诱发大鼠急性EAE;治疗组在模型组基础上予以火把化根(600mg.kg-1.d-1)治疗,观察临床表现并评分;HE染色和Loyez氏髓鞘染色观察病理和髓鞘改变;免疫组化技术测定脑和脊髓的L-选择素水平。结果:治疗组未出现临床症状,L-选择素为1.88±0.64,与模型组比较P<0.05;脑和脊髓小血管周围炎症细胞浸润明显减少;髓鞘结构完整。结论:火把化根片对EAE有治疗作用,其机制与抑制L-选择素表达有关。
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Key words
Colquhoumai root tablet,L-selectin,Experimental allergic encephalomyelitis
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