Synthetic approaches to 5,7-disubstituted imidazo[5,1-f][1,2,4]triazin-4-amines
Tetrahedron Letters(2010)
Abstract
The preparation of 5,7-disubstituted imidazo[5,1-f][1,2,4]triazin-4-amines, exemplified by 5-[3-(benzyloxy)phenyl]-7-cyclobutylimidazo[5,1-f][1,2,4]triazin-4-amine, was developed through a linear and three convergent synthetic strategies, with the latter providing the greatest flexibility for diversification at the 5-position at the last step of the synthesis.
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Key words
Synthesis
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