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Synthesis and biological activity of 2H-quinolizin-2-one based p38α MAP kinase inhibitors

Robert M. Tynebor,Meng-Hsin Chen,Swaminathan R. Natarajan,Edward A. O’Neill,James E. Thompson,Catherine E. Fitzgerald,Stephen J. O’Keefe,James B. Doherty

Bioorganic & Medicinal Chemistry Letters（2010）

Cited 14|Views42
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Abstract
The development and synthesis of potent p38α MAP kinase inhibitors containing a 2H-quinolizin-2-one platform is described. Evolution of the 2H-quinolizin-2-one series from an early lead to solving off target activity and pharmacokinetic issues is also discussed.
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p38α inhibitors,MAP kinase
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