ChemInform Abstract: The Highly Enantioselective Phase-Transfer Catalytic Mono-Alkylation of Malonamic Esters.

Mi-hyun Kim,Sea-hoon Choi,Yeon-Ju Lee,Jihye Lee,Keepyung Nahm,Byeong-Seon Jeong,Hyeung-geun Park,Sang-sup Jew

Cheminform（2009）

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摘要

The phase-transfer catalytic alkylation of N,N-dialkylmalonamic tert-butyl esters in the presence of 1 mol% of (S,S)-3,4,5-trifluorophenyl-NAS bromide afforded highly enantioselective (S)-mono-α-alkylated products (up to 96% ee), which could be readily converted into versatile chiral building blocks without loss of chirality.

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malonamic esters,cheminform abstract,phase-transfer,mono-alkylation

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