Pharmacokinetic Study of the Baicalin from Ultramicro-pulverised Powder of Huanglian jiedusan(HLJDS) in Rabbits
Chinese Journal of Animal and Veterinary Sciences(2007)
Abstract
High performance liquid chromatography(HPLC) was applied to determine the concentrations of plamsa baicalin in two groups of rabbits after administering the ultramicro-pulverised powder and the ordinary powder of HLJDS(in water suspension) by gastrogavage respectively.The plasma concentration-time data of baicalin were dealt with Pharmaceutical Kinetics Software(PKS).Pharmacokinetics characteristics of both the ultramicro-pulverised powder and ordinary powder of HLJDS were compared.The results showed that the best pharmacokinetic model of baicalin in either group was two-compartment open model.The main pharmacokinetic parameters of baicalin of ultramicro-pulverised powder were as follows: Ka=0.497 h-1,t1/2α=2.556 h,t1/2β=8.46 h,AUC0→∞=3.401 μg·h/mL,Vd=6.752 L/kg,Tpeak=3.005 h,Cmax=0.311 μg/mL;The main pharmacokinetic parameters of baicalin of the ordinary powder were as follows:Ka=0.419 h-1,t1/2α=2.74 h,t1/2β=5.83 h,AUC0→∞=2.611 μg·h/mL,Vd =12.890 L/kg,Tpeak=3.645 h,Cmax=0.215 μg/mL.As compared to the baicalin from ordinary powder,the relative bioavailability of baicalin from ultramicro-pulverised powder was increased by 30.26%.These data presented above indicated that the bioavailbility of baicalin from HLJDS could be greatly improved after processing and preparing by the technique of ultromicro-pulverization.
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Key words
baicalin,ultramicro-pulverised powder,Huanglian jiedusan(HLJDS),bioavailability,pharmacokinetics
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