Pyrrolo[3,2,1-Ij]Quinoline Derivatives, A 5-Ht2c Receptor Agonist With Selectivity Over The 5-Ht2a Receptor: Potential Therapeutic Applications For Epilepsy And Obesity

M Isaac,A Slassi,A O'Brien,L Edwards,N MacLean,D Bueschkens,D K Lee,K McCallum,I De Lannoy,L Demchyshyn,R Kamboj

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2000）

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摘要

A series of pyrrolo[3,2,1-ij]quinoline derivatives was synthesized, evaluated for their activity against the 5-HT2c and 5-HT2a, receptors and found to be agonists at 5-HT2c with selectivity over 5-HT2a. (C) 2000 Elsevier Science Ltd. All rights reserved.

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关键词

receptor,potential therapeutic applications,epilepsy

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