Der p2重组BCG对哮喘小鼠气道炎症的抑制作用
Journal of the Fourth Military Medical University(2009)
Abstract
目的:观察胞壁型屋尘螨抗原Derp2重组卡介苗(Derp2rBCG)对哮喘小鼠气道炎症的抑制作用.方法:实验分4组,小鼠分别给予生理盐水、BCG或Derp2rBCG处理,然后以Derp2为变应原建立哮喘模型,正常对照组给予生理盐水致敏及气道内滴入,取肺泡灌洗液、肺组织标本,观察肺部炎症细胞浸润、气道杯状细胞增殖及肥大细胞脱颗粒情况.结果:①Derp2rBCG下调了哮喘小鼠气道局部炎症;②Derp2rBCG减轻了哮喘小鼠肺组织中的炎症细胞浸润;③Derp2rBCG可以减轻哮喘小鼠气道粘液高分泌现象并下调杯状细胞数量;④Derp2rBCG减轻了哮喘小鼠气道中的肥大细胞脱颗粒现象.结论:Derp2rBCG是一种有效的哮喘免疫治疗方法.
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Key words
bacillus calmette guerin,asthma,dermatophagoides protein ⅱ group
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