Physiological Role Of Type Ii Bone Morphogenetic Protein Receptor And Its Interacting Molecules In Bone Morphogenetic Protein Signaling

Type II bone morphogenetic protein (BMP) receptor (BMPRII) is a membrane receptor containing a unique tail domain. This kinase receptor is involved in various biological processes, including bone formation. Recent studies have revealed that novel BMPRII-interacting proteins are involved in the Smad signaling pathway or in the non-Smad signaling pathway. This report focuses on BMPRII-mediated signal transduction and provides advanced insights into the physiological roles of BMPRII.