Study on the Model of T2DM of Cynomolgus Induced by High-energy Diet

A total 36 cynomolgus were used to induce the process model of type 2 diabetes(T2DM) by feeding with standard basic feed,high-sugar,high-fat and both high-sugar fat diet,respectively,for 24 months.The development and progression of T2DM were monitored through body weight,blood biochemical index,oral glucose tolerance and urinalysis test every six months.The results showed that the level of fasting plasma glucose(FPG),triglycercide(TG),cholesterin(CHO),high density lipoprotein cholesterin(HDL) and low density lipoprotein cholesterin(LDL) of cynomolgus in high-energy groups were significantly higher than that in the initial individuals.The time when high-sugar objects had clinical symptoms was earlier than that in other high-energy ones,there were still no sample in clinical phase of the both high-sugar fat groups.The levels of serum lipids for different dietary groups were different in the same phase,but they were basically the same in clinical phases.In conclusion,this method to induce the T2DM process model of cynomolgus by high-energy diet was feasible.