大鼠肝脏缺血再灌注损伤程度判定指标的选择
Chinese Journal of General Surgery(2008)
Abstract
目的探讨肝脏缺血再灌注(I/R)损伤程度及其判断指标的选择。方法建立大鼠肝脏局部I/R模型,测定大鼠肝脏缺血60,90min再灌注0,1,2,4,6,12,24,48h时的血清丙氨酸转氨酶(ALT)水平,并行病理检查(相对细胞死亡率)。参照本院I/R损伤分级标准重新将动物分为4个不同的I/R损伤程度的实验组,分析ALT水平与病理改变的关系。结果缺血60min组中轻度I/R损伤占75.0%,中度I/R损伤占14.6%,重度I/R损伤占10.4%;缺血90min组中轻度I/R损伤占41.7%,中度I/R损伤占25.0%,重度I/R损伤占16.7%,严重度I/R损伤占16.7%。损伤程度越重细胞死亡率越高,ALT水平也越高。结论ALT水平可直接反映肝脏I/R损伤程度;损伤程度越重,转氨酶水平越高,细胞死亡率也越高。
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Key words
Rats,Ischemia Reperfusion Injury,Liver/ blood supply
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