Clinical effect of biafine cream to prevent radiation-induced dermal injury on the breast in breast carcinoma patients after modified mastectomy

Objective:To observe the clinical effect of biafine cream to prevent acute radiation-induced dermal injury on the breast in breast carcinoma patients after modified mastectomy.Methods:Fifty breast carcinoma patients who accepted radiotherapy of breast after mastectomy were randomized into two groups,every group were 25,the treatment group was given biafine cream application since the first radiotherapy while the control group without this medication when general and health education program about radiotherapy was given.Results:The rates of acute radiation dermatitis of grade Ⅰ,Ⅱ,Ⅲ in the treatment group and in the control group were 28%,52%,20% and 60%,28%,12%,respectively;acute radiation dermatitis occurred before 25Gy were 80% and 56%,respectively.Conclusion:Biafine cream can prevent acute radiation response in skin on the breast in breast carcinoma patients after modified mastectomy,and can postpone the occurrence of acute radiation dermatitis.