Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives
Bioorganic & Medicinal Chemistry Letters（2006）
摘要
Nanomolar inhibitors of P. falciparum enoyl acyl carrier protein reductase are presented that demonstrate potent anti-parasitic efficacy.
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关键词
Anti-malarial,Phenol,Diaryl ether
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