肢体缺血预处理对大鼠海马CA3区和齿状回区p38 MAPK和HSP 70表达的影响
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology（2013）
Abstract
目的:观察肢体缺血预处理(LIP)后大鼠海马CA3区和齿状回区(DG)p38MAPK和HSP70的表达,以进一步探讨CA3区和DG区的缺血耐受机制.方法:96只Wistar大鼠随机分为sham组和LIP组,LIP组进一步分为LIP6h、LIP 12h、LIP1d、LIP2d、LIP3d、LIP4d和LIP5d亚组.方法:应用免疫组织化学和Western blot方法观察大鼠海马CA3区及DG区p38 MAPK和HSP70的表达.结果:免疫组化及Westem blot结果显示,与sham组相比,LIP后大鼠海马CA3区及DG区p-p38 MAPK及HSP 70的表达呈现出动态的变化,其中p-p38 MAPK的表达于LIP后1d明显增加、3d达到高峰,LIP后4d逐渐下降；HSP 70的表达则于LIP后2d明显增加、3d达到高峰,LIP后4d逐渐下降.结论:LIP上调了大鼠海马CA3区和DG区p38 MAPK和HSP 70的表达.
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Key words
limb ischemic preconditioning,hippocampus,hsp 70,p38 mapk
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