produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly)

Pelger-Huët anomaly (PHA; OMIM *169400) is an autosomal dominant disorder characterized by abnormal nuclear shape and chromatin organization in blood granulocytes. Affected individuals show hypolobulated neutrophil nuclei with coarse chromatin. Presumed homozygous individuals have ovoid neu- trophil nuclei, as well as varying degrees of developmental delay, epilepsy and skeletal abnormalities1-3. Homozygous off- spring in an extinct rabbit lineage showed severe chondrodys- trophy, developmental anomalies and increased pre- and post- natal mortality4,5. Here we show, by carrying out a genome-wide linkage scan, that PHA is linked to chromosome