1904 a prospective study of the relationship between a systemic inflammation prognostic score, tumour inflammatory cell infiltrate and cancer specific survival in patients undergoing treatment for bladder cancer

You have accessJournal of UrologyBladder Cancer: Staging1 Apr 20111904 A PROSPECTIVE STUDY OF THE RELATIONSHIP BETWEEN A SYSTEMIC INFLAMMATION PROGNOSTIC SCORE, TUMOUR INFLAMMATORY CELL INFILTRATE AND CANCER SPECIFIC SURVIVAL IN PATIENTS UNDERGOING TREATMENT FOR BLADDER CANCER Tahir Qayyum, Peter McArdle, Mustafa Hilmy, James Going, Mark Underwood, Donald McMillan, and Joanne Edwards Tahir QayyumTahir Qayyum Glasgow, United Kingdom More articles by this author , Peter McArdlePeter McArdle Glasgow, United Kingdom More articles by this author , Mustafa HilmyMustafa Hilmy Glasgow, United Kingdom More articles by this author , James GoingJames Going Glasgow, United Kingdom More articles by this author , Mark UnderwoodMark Underwood Glasgow, United Kingdom More articles by this author , Donald McMillanDonald McMillan Glasgow, United Kingdom More articles by this author , and Joanne EdwardsJoanne Edwards Glasgow, United Kingdom More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2028AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of this study was to assess the relationship between a systemic inflammation prognostic score (mGPS), the tumour inflammatory cell infiltrate as measured by the Klintrup and Makinen score and cancer specific survival in patients undergoing treatment for bladder cancer. METHODS In all, 47 with localised disease and 21 with muscle invasive disease who had undergone treatment were included. The mGPS response was constructed by measuring the C-reactive protein, (CRP) and albumin concentrations and the Klintrup and Makinen score was constructed for the local inflammatory response. Pathological parameters such as grade, T stage and tumour necrosis were also assessed. RESULTS In total, 68 patients were included. Median follow was 47 months. 23 patients died of their disease. On univariate analysis, T stage (p<0.001), Grade p<0.001), Tumour Necrosis (p=0.002) and mGPS (p=0.003) were significant predictors of cancer specific survival. On multivariate analysis of the significant individual covariates T stage (hazard ratio 23.33, 95% confidence interval 5.01–107.04, p<0.001) and mGPS (hazard ratio 2.24, 95% confidence interval 1.20–4.20, p=0.012) were significant independent predictors of cancer specific survival. CONCLUSIONS The presence of a preoperative systemic inflammatory response is an independent predictor of poor cancer specific survival in patients undergoing treatment for bladder cancer. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e761 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Tahir Qayyum Glasgow, United Kingdom More articles by this author Peter McArdle Glasgow, United Kingdom More articles by this author Mustafa Hilmy Glasgow, United Kingdom More articles by this author James Going Glasgow, United Kingdom More articles by this author Mark Underwood Glasgow, United Kingdom More articles by this author Donald McMillan Glasgow, United Kingdom More articles by this author Joanne Edwards Glasgow, United Kingdom More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...