Transfusion in the Face of Autoantibodies
msra(1998)
摘要
It is not unusual for patients to have antibodies directed against their own red blood (RBCs).In many cases, these autoantibodies
are totally benign and cause no clinical problems. However, in some instances autoantibodies can cause hemolysis in the patient.
If this hemolysis is substantial, an autimmune hemolytic anemia will develop with significant clinical signs and symptoms.
Autoantibodies are readily detected in th Blood Bank laboratory, regardless of whether the autoantibody is pathogenic or benign.
This can make it piossible to find compatible blood. In this chapter, the differences between benign and clinically significant
autoantibodies are discussed. Next, we discuss the pathophysiology, clinical presentation, laboratory test results, and transfusion
therapy for autoimmune hemolytic anemias. Finally, we discuss other situations in which potentially clinically significant
autoantibodies can arise.
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