高剂量吉非替尼治疗晚期非小细胞肺癌脑转移并文献复习
Journal of Modern Oncology(2013)
Abstract
目的:探索高剂量吉非替尼治疗晚期非小细胞肺癌脑转移的有效性及安全性。方法:2例患者口服吉非替尼250mg/d出现脑转移后,吉非替尼剂量增加至500mg/d,观察高剂量吉非替尼有效性和安全性。结果:口服吉非替尼500mg/d一个月后,2例患者肺部病灶均控制良好,1例脑部病灶达PR,1例脑部病灶SD。毒副反应主要为皮疹与腹泻,经对症处理后均能耐受。结论:高剂量吉非替尼治疗晚期NSCLC脑转移可能有效,值得临床进一步观察。
MoreTranslated text
Key words
non-small cell lung cancer,brain metastases,high dose gefitinib
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined