Influence of higenamine hydrocloride myocardial stress test on heart rate,blood pressure,myocardial oxygen consumption

OBJECTIVE To explore the influence of higenamine hydrochloride(HG) myocardial stress test on heart rate(HR),blood pressure(BP),myocardial oxygen consumption(MOC) and its mechanism of action.METHODS HG was injected intravenously in patients.HR,systolic blood pressure(SBP) and diastolic blood pressure(DBP) were recorded after higenamine(0.5,1.0,2.0,4.0 μg·kg-1·min-1) was introduced,and compared with those before treated with higenamine.RESULTS The HR(t=9.950,P0.001) and MOC(t=8.333,P0.001) were increased after intravenous administration of HG.HG did not cause significant change in SBP(t=1.633,P=0.107),but a slight decrease in DBP(t=4.895,P0.01) was found.CONCLUSION HG could increase HR and MOC,it had no significant changes in BP.It can be used in pharmacological stress test with remarkable safety.