Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase.

Yongqi Deng,Gerald W Shipps,Tong Wang,Janeta Popovici-Muller,Kristin E Rosner,M Arshad Siddiqui,Jose Duca,Alan B Cooper,Michael Cable

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

The design, synthesis and evaluation of a series of 4H-Pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase are described.

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关键词

Hepatitis C virus,Polymerase,Pyrazolopyrimidin-ones,Anti-viral agents

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