Robust Ms Serum Sample Classification In Proteomics By The Use Of Inverse Problems
2012 IEEE INTERNATIONAL WORKSHOP ON GENOMIC SIGNAL PROCESSING AND STATISTICS (GENSIPS)(2012)
摘要
In this communication, we address the problem of robust classification of proteomic serum samples. We propose coupling classification with the inverse problem methodology. The analytical chain comprising a liquid chromatograph and a mass spectrometer in Selected Reaction Monitoring mode is modelled, integrating an implicit hierarchy. We solve the inverse problem by the means of full-Bayesian statistics, resorting to stochastic sampling algorithms for the numerical computations. We compare our joint Inversion-Classification to state-of-the-art methods (Naive Bayes, logistic regression, fuzzy c-means) using sequential estimations and show very encouraging results on simulated multi-class data.
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关键词
classification, inverse problems, Bayesian statistics, hierarchical forward model, proteomics, SRM, mass spectrometry
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