Affection of Sinomenine on the Kidney Pathology and Expression of ICAM-1 in the Rats with Mesangial Proliferative Glomerulonephritis

To explore affection of Sinomenine(SIN) on the kidney pathology and Intercellular cell adhesion molecule-1(ICAM-1) expression in rats with mesangial proliferative glomerulonephritis(MsPGN).The test uses the improvement chronic serum sickness nature MsPGN model,with the light mirror observing mesangial region and kidney tubules-mesenchyma,using immunohistochemical method observe the expression of ICAM-1,at the same time,carries on the semi-definite quantity analysis with the pathology image analysis system.The results showed that compared with the normal group,mesangial matrix index(%) remarkably heighten(P0.01) and capillary lumen diameter(μm) obviously reduce.Compard with the model group,in SIN group,mesangial matrix index(%) remarkably reduce(P0.01) and capillary lumen diameter(μm) obviously improve(P0.01).In the nephridial tissue immunohistochemistry result showed that SIN can obviously reduce Relative amount(%) and Density expression(P0.01).Comparing between two treatments groups,although the result of SIN group is lower than TWP group but the two comparison have no the remarkable difference(P0.05).This result suggested that SIN can effectively reduce the kidney pathological lesion,refrain the expression of ICAM-1.