HBV-PreS1Ag、HBV传统血清标志物及HBV-DNA检测意义的探讨
The Journal of Medical Theory and Practice(2009)
Abstract
目的:分析HBV前S1抗原和血清标志物之间的关系,探讨前S1抗原检测在临床上的应用价值.方法:收集382例乙型肝炎血清标本,采用酶联免疫吸附试验(ELISA)检测HBV血清标志物和PreS1抗原,用聚合酶链反应(PCR)检测HBV-DNA,对检测结果进行比较.结果:382例乙型肝炎患者PreS1抗原和HBV-DNA的检出率分别为33.8% 和40.8%;其中HBeAg阳性144例中,PreS1抗原阳性112例,HBV-DNA阳性134例,阳性率分别为77.8%和93.1%;HBeAg阴性238例中,PreS1抗原阳性17例,HBV-DNA阳性22例,阳性率分别为7.1%和9.2%.HBV-DNA检出率稍高于PreS1Ag的检出率,但两者的检出率差异均无统计学意义(P>0.05).结论:HBV前S1蛋白可反映HBV复制状况,与HBV-DNA结果的一致性较好,可作为临床上HBV感染诊断和监测的一项指标.
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Key words
HBeAg,HBV-DNA,HBV,PreS1Ag
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