Research Progress in Effect of Sphingosine 1-phosphate on Cardiovascular System

Sphingosine1-phosphate(S1P) is one of the intermediate products of the metabolism of sphingomyelins.S1P mainly exists in lipoprotein-bound form in plasma.It has five kinds of specific receptors.They are widely expressed in endothelial cells,vascular smooth muscle cells and cardiac myocytes.Mainly through specific cell surface receptors(of S1P receptor,the combination of S1PR) S1P plays a wide range of biological effects,such as vascular endothelial protection,inhibition of smooth muscle cell migration,myocardial ischemia / reperfusion injury protection,and inhibition of the expression of adhesion molecules.The development of the cardiovascular system,the pathophysiological process of atherosclerosis and myocardial ischemia / reperfusion injury all involve the effects of S1P.