Akt activation prevents Apop-1-induced death of cells.
Biochemical and Biophysical Research Communications(2008)
摘要
Apop-1 is a novel protein identified in cultured atherosclerotic smooth muscle cells of ApoE-deficient mice, and the expression of the Apop-1 protein induces the death of cultured cells. Insulin-like growth factor-1 (IGF-1) is a well-characterized survival factor for VSMC; however, the interaction between Apop-1 and survival factor IGF-1 in the mediation of cell death is poorly understood. In this report, we show that the IGF-1 signaling cascade protects VSMC against Apop-1-induced death. Furthermore, our data indicate that the inhibition of Apop-1-induced death by IGF-1 is mediated by the activation of the PI3K/Akt signaling pathway.
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关键词
IGF-1,VSMC,Apop-1,PTP,BH,IGF-1R,PI3K,MAPK,GFP,DN-Akt,CA-Akt
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