Endurance Training In Women: Effects On Ldl Oxidation And Lipids

1487 Most aggressive for the formation of the atheromatic plaque is oxidized LDL. Endurance training leads to a protection of the arteries by an elevation of HDL and a reduction of LDL. PURPOSE: To determine the effect of endurance training on the oxidation of LDL in vitro and to correlate possible effects to changes in cholesterol, triglycerides, lipoproteins and lipoprotein (a). METHODS: 20 untrained women and 10 controls agreed to participate in an 8-week running program, performed 3 times a week for 30 min at an intensity of the 4 mmol/l lactate threshold. The intensity was derived from a stepwise spiroergometric test before the start of the program. Venous blood was taken 30 min before and 3 min after the test. The test was repeated after the training. The oxidation of LDL in vitro, the products of lipidperoxidation malondialdehyd and conjugated diens were measured as well as cholesterol, triglycerides and lipoproteins. RESULTS: With a compliance of 97%, the running speed was increased by 1.5 km/h and the VO2max from 38 to 41 ml•min−1•kg−1 at the same maximum lactate. The submaximum running speed increased by 1.8 km/h. Training induced differences between the training and control groups in LDL and HDL2, but not for lagtime of LDL, malondialdehyd and conjugated diens, HDL3, VLDL, triglycerides, total cholesterol and lipoprotein (a). LDL was reduced from 122 to 105 mg/dl and HDL2 rose from 18.4 to 21.2 mg/dl (p<0.01). CONCLUSIONS: In young women, the antioxidative protection for LDL may not be improved by endurance training of eight weeks. Only the lipoproteins HDL2 and LDL showed beneficial changes.