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N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.

Haishan Wang,Niefang Yu,Hongyan Song,Dizhong Chen,Yong Zou,Weiping Deng,Pek Ling Lye,Joyce Chang,Melvin Ng,Stéphanie Blanchard,Eric T. Sun,Kanda Sangthongpitag,Xukun Wang,Kee Chuan Goh,Xiaofeng Wu,Hwee Hoon Khng,Lijuan Fang,Siok Kun Goh,Wai Chung Ong,Zahid Bonday,Walter Stünkel,Anders Poulsen,Michael Entzeroth

Bioorganic & Medicinal Chemistry Letters（2009）

Cited 33|Views26
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Abstract
SAR has been established for R1, R2 and Z of benzimidazole-based HDAC inhibitors (XV). Compound 23 (SB639) is a promising lead for further optimization towards a clinical candidate.
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Key words
HDAC inhibitor,Benzimidazole,Hydroxamic acid,SAR,Anticancer
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