林丽珠辨治表皮生长因子受体抑制剂相关皮疹的经验探析
World Science and Technology(Modernization of Traditional Chinese Medicine and Materia Medica)(2009)
Abstract
目的:总结林丽珠教授对EGFRIs皮疹病因病机的认识及辨治疗效。方法:28例患者中治疗组17例,予荆防四物汤+皮肤外洗方治疗EGFRIs所致皮疹,空白对照组11例。观察两组前后皮肤毒性分级变化,评估治疗组药疹治疗效果,并比较半年后EGFRIs疗效及患者生存情况。结果:治疗组17例,痊愈0例,好转15例,无效2例,总有效率88.24%。治疗后主观症状显著改善(P<0.01);发疹密度下降,尤其是脓疱样皮疹出现减少;风热型、胃热型比其它证型疗效更佳(P<0.05);半年后随访两组在GFRIs疗效上无显著统计学差异(P>0.05)。结论:本方案辨证加减治疗EGFRIs相关皮疹有确切的疗效,加用中药辨证治疗半年内对EGFRIs疗效无明显影响。
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Key words
EGFRIs,Syndrome differentiation and treatment,Drug eruption,YIN-deficiency of the lung and kidney
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