Synthesis And Antimicrobial Activity Of 4-Amino Trinems

This article deals with the study carried out on the synthesis of 4-amino substituted trinems 1 starting from the key-intermediate (3S,4R)-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-4-[(1'R, 2'S, 3'R)-1',2'-epoxycyclohex-3'-yl]azetidin-2-one 2. In particular, epoxide opening with various amines and subsequent cyclization to the corresponding trinems were explored. Their synthesis and antimicrobial activity are reported. Copyright (C) 1996 Elsevier Science Ltd