Laparoscopic Adrenalectomy in Children: Experience of the Groupe d'Etude en Coeliochirurgie Infantile in 16 Cases

Background: Conventional adrenalectomy usually necessitates a large incision. In some cases, laparoscopic adrenalectomy offers a less aggressive solution to the patient's problem. Patients and Methods: Laparoscopic adrenalectomy for clearly defined lesions was performed in five girls and nine boys with a mean age of 9 years. The indication was incidental discovery in four patients, hypertension in six (two of whom had von Hippel Lindau syndrome), Cushing's disease in two, and gynecomastia or premature puberty in one patient each. The lesion was on the right side in five patients and the left side in six and was bilateral in three. The mean diameter was 35 mm. The urinary concentrations of vanillylmandelic acid and homomandelic acid were normal in five patients with neurogenic tumors and elevated in five patients with pheochromocytoma. An anterior transabdominal approach was used in nine patients and a lateral retroperitoneal approach in seven. Results: The operating time ranged from 35 to 320 minutes. There were three conversions to open surgery (20%). There were no perioperative or postoperative complications. Histologic examination revealed 13 benign lesions (7 pheochromocytomas, 3 ganglioneuromas, 2 cortical adenomas, and 1 hyperplasia), 1 malignant lesion (N-Myc-negative neuroblastoma, which was removed after conversion to open surgery), and two indeterminate lesions. Of the latter lesions, one was an N-Myc-negative gangioneuroblastoma, and the other was an adrenocortical tumor that was treated initially by local excision and 1 month later by total adrenalec via an open approach. There were no tumor remnants in the specimen. All patients are alive without evidence of recurrence with follow-up of 6 months to 4 years. Conclusions: The laparoscopic approach should be reserved for well-defined lesions <0.5 cm that are probably benign, although the nature of the lesion can be difficult to define preoperatively. The indications can be extended to stage I nonsecreting neuroblastoma in some situations and, for some surgeons, to tumors of stage IV or V. There seems to be no age or weight limit. A left-sided lesion usually is resected via a lateral retroperitoneal approach and a right-sided lesion by an anterior transperitoneal approach, but the details of the technique with the anatomy and the surgeon's experience. Oncologic principles must be respected, and the rate of conversion to open surgery is high.