Correlation of Aspirin Resistance with Gene Polymorphisms of Cyclooxygenase

Objective: To explore the relationship between COX-1-1676AG,COX-2-765GC single nucleotide polymorphisms(SNP) and aspirin resistance in patients with Ischemic stroke.Methods: One hundred and sixty-nine patients with Ischemic stroke taking 100 mg aspirin at least 7 days were selected and divided into the aspirin sensitive group(AS) and non-aspirin sensitive group(NAS) according to thrombelastography(TEG).In these patients,COX-1-1676AG,COX-2-765GC gene polymorphisms were analyzed by polymerase chain reaction and DNA sequencing assay.Results: Patients were divided into NAS(66 cases) and AS(103 cases).There were significant differences in the genotype distribution and allele frequency of COX-1-1676AG SNP between two groups(P=0.016 and P=0.008).There were no significant difference in the genotype distribution and allele frequency of COX-2-765GC SNP between two groups(P=0.084 and P=0.090).Conclusion: In the patients with ischemic stroke,COX-1-1676AG polymorphism may be related to the aspirin resistance;however,COX-2-765GC polymorphism was not associated with the aspirin resistance.