Preparation of Four Types of Coenzyme Q10/γ-Cyclodextrin Supramolecular Complexes and Comparison of Their Pharmaceutical Properties

In this study, we prepared four kinds of complexes or Coenzyme Q10 (CoQ10) with gamma-cyclodextrin (gamma-CyD) by the kneading methods and the solubility methods with or without heating, and compared their pharmaceutical properties. Differential scanning calorimetrical curves and powder X-ray diffraction patterns showed that the complexes formed pseudorotaxane-like supramolecular structure, although included free gamma-CyD and CoQ10, when prepared by the kneading method and solubility method without heating. At the preparation process, a heating improved the complexation of CoQ10 with gamma-CyD in the both methods. The dispersion rate of CoQ10 in water increased in the order of CoQ10 alone approximate to physical mixture with gamma-CyD << solubility/heating product更多