Discovery and functional evaluation of diverse novel human CB1 receptor ligands
Bioorganic & Medicinal Chemistry Letters（2009）
摘要
hCB1 Antagonist pharmacophore→Virtual Screening→Binding Assay→30 diverse novel hCB1 ligands→Functional Assay→At least 11 inverse agonists.
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关键词
CB1,CB2,CNS,FFA,GPCR,MMFF,NA,NSB,SAR,SPI,VS
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