基质金属蛋白酶组织抑制因子-1基因多态性与慢性牙周炎相关性研究
Journal of Practical Stomatology(2009)
Abstract
目的:探讨基质金属蛋白酶组织抑制因子-1(TIMP-1)基因多态性与慢性牙周炎易感性的相关性。方法:从广东汉族人群中收集70例慢性牙周炎(CP)患者及74例牙周健康对照者的颊黏膜拭子,以Chelex-100法提取DNA,采用聚合酶链反应-限制性片段长度多态方法对TIMP-1+372T/C(rs4898)、TIMP-1+533C/T(rs1062849)多态性进行检测,χ2检验分析组间等位基因分布和基因型频率的差异。结果:TIMP-1+372位C、T等位基因在CP组和对照组的分布差异无统计学意义(P=0.897,OR=1.062)。TIMP-1+533C/T多态性未检出。结论:TIMP-1+372T/C多态性与中国广东汉族人慢性牙周炎的患病易感性无关,且该人群中不存在TIMP-1+533C/T多态性。
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Key words
Allele,Tissue inhibitor of matrix metalloproteinase,Single nucleotide polymorphism,Chronic periodontitis
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