脑梗死患者血浆型血小板活化因子乙酰水解酶基因9号外显子突变的研究
Chinese Journal of Geriatric Heart Brain and Vessel Diseases（2006）
Abstract
目的研究血浆型血小板活化因子乙酰水解酶(PAF-AH)基因9号外显子突变与动脉硬化性脑梗死(ACI)的关系.方法应用多聚酶链反应(PCR)及变性高效液相色谱(DHPLC),分析150例ACI患者[ACI组(其中分进展组50例,无进展组100例)]和100例健康体检者(对照组)血浆型PAF-AH 9号外显子基因型及突变等位基因频率.结果ACI组血浆型PAF-AH9号外显子突变(VaL279Phe)基因型及突变等位基因的频率高于对照组,差异有显著性(P＜0.05);伴不同危险因素ACI患者基因突变的差异无显著性(P＞0.05).结论ACI患者血浆型PAF-AH基因9号外显子突变基因型及突变等位基因显著增高.
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Key words
chromatography,platelet activating factor,brain infarction,mutation,polymerase chain reaction,high pressure liquid
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