Continuous Synthesis of Epoxides from Alkenes by Hydrogen Peroxide with Titanium Silicalite‐1 Catalyst Using Flow Reactors.

The inside cover picture of a waterfall stream illustrates the continuous synthesis of various epoxides from olefins, with hydrogen peroxide as an oxidant, catalyzed by titanium silicalite-1 (TS-1). This reaction is applicable to the epoxidation of more than 20 olefins and the only co-product is water. As a typical example, 4-phenyl-1,2-epoxybutane was continuously synthesized in over 90% yield for more than 150 hours, and ICP-MS/MS observations showed that little or no Ti loss from TS-1 was observed. Details can be found in the Communication by Yoshihiro Kon and co-workers (Y. Kon, T. Nakashima, Y. Makino, H. Nagashima, S. Onozawa, S. Kobayashi, K. Sato, Adv. Synth. Catal. 2023, 365, XXXX–XXXX; DOI: 10.1002/adsc.202300181).