Effects of Jiangzhi II Preparation on Experimental Hyperlipemia and Atherosclerosis in Rabbits

Objective:To study the effects of Jiangzhi Ⅱ Preparation on experimental hyperlipemia and atherogensis in rabbits.Method: The hyperlipemia and atherosclerosis model in rabbits was established by feeding high-fat diet.All animals were randomly divided into normal group,model group,simvastatin group,Jiangzhi Ⅱ high,middle and low dose groups(4.6,2.3,1.2 g · kg-1).After eight weeks of treatment,the content of total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),high density lipoprotein(HDL),nitric oxide(NO) and endothelin(ET-1) in serum were determined.The extent of aortic atherosclerosis was observed and the pathological examination was done.Result: In the Jiangzhi Ⅱ treatment groups,the concentration of TC,TG,LDL,ET-1 in serum was decreased markedly,the concentration of HDL and NO was increased remarkably,the extent of aortic atherosclerosis and the atherosclerotic lesion were lightened obviously.Conclusion: Jiangzhi Ⅱ Preparation can effectively decrease the serum lipids and prevent the formation of atherosclerosis.