How Pure is Your Thiosialoside? A Reinvestigation into the HPLC Purification of Thioglycosides of N-acetylneuraminic Acid
Glycoconjugate journal(1999)
摘要
The synthesis of thiosialosides as potential biological probes for investigations involving the use of sialic acid-recognising proteins has been reinvestigated. It has been found that the most efficient method for the preparation of thiosialosides free from any 2,3-didehydro sialic acid contaminants involves an intermediate HPLC purification of thiosialosides as their methyl esters. Subsequent methyl ester hydrolysis provides thiosialosides (eg. 6 and 14) which are suitable for studies involving the use of sialic acid-recognising proteins.
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关键词
thiosialosides,sialic acids,thioglycosides,HPLC purification,biological probes
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