聚乙二醇单甲醚-聚谷氨酸的合成与表征
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi(2006)
Abstract
以聚乙二醇单甲醚为原料在溶剂中与萘钾反应,形成聚乙二醇单甲醚的钾盐活性中间体,再与对甲苯磺酰氯反应得到聚乙二醇单甲醚对甲苯磺酸酯,进而反应生成氨基聚乙二醇单甲醚,并用此引发γ-苄基-L-谷氨酸-N-羧酸酐,生成嵌段共聚物聚乙二醇单甲醚-聚苄酯谷氨酸,然后用碱脱去苄酯保护基,得到水溶性的聚乙二醇单甲醚-聚谷氨酸。用红外光谱,核磁共振,凝胶渗透色谱对聚合物结构进行了表征。该嵌段共聚物在药物控制释放研究中具有重要的应用价值。
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Key words
amine-terminated peg γ-benzyl-l-glutamate ncarboxy poly(ethylene glycol)-co-poly(glutamate acid) block copolymer
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