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牡蛎天然活性肽BPO-1诱导人胃腺癌BGC-823细胞凋亡的形态与超微结构观察

Song-lin SHI,Peng LI,Qi-fu LI,Ying LIANG

Chinese Journal of Marine Drugs（2007）

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Abstract
目的 观察BPO-1对人胃腺癌BGC-823细胞形态与超微结构的影响,以探索BPO-1对胃癌细胞的作用机制.方法 采用酸抽提、凝胶柱层析等方法,从牡蛎体内分离提取到牡蛎天然活性多肽组分BPO-1,以细胞凋亡诱导物姜黄素和癌细胞分化诱导物HMBA为平行对照,用光镜、透射电镜观察BPO-1处理细胞的形态和超微结构变化.结果 经处理后的BGC-823细胞体积缩小、染色质凝聚、线粒体空泡化、内质网腔扩大和出现凋亡小体等多种典型的细胞凋亡形态和超微结构特征.结论 牡蛎天然活性肽BPO-1对人胃腺癌BGC-823细胞凋亡的诱导具有显著作用.
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morphology and ultrastructure,oyster bioactive peptides,apoptosis,gastric adenocarcinoma cells
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