Extreme Whole-Body Hyperthermia with Water-Filtered Infrared-A Radiation
Hyperthermia in Cancer Treatment: A Primer(2000)
Abstract
The testing of various methods to realise extreme whole-body hyperthermia (eWBH) finally led to the utilisation of radiative
systems. Among these the application of water-filtered infrared-A radiation (wIRA) distinguished itself by its high penetration,
all the way into the capillary bed of the skin. With wIRA the interfering infrared-B and the infrared-C is eliminated from
the heat radiation. Thus a clearly higher radiation power can be applied at a tolerable level than by applying unfiltered
heat radiation. In two independent phase I clinical studies the high tolerance of eWBH (approx. 42°C/60 min) was proven in
the scope of the so-called systemic cancer multistep therapy (sCMT) while applying wIRA. First proof of the retardation of
tumour progression could be carried out by a retrospective observation study of over 490 sCMT treatment courses of cancer
patients with various different tumour entities at an advanced stage. A phase I/II clinical study on the treatment of 19 patients
with metastatic colorectal cancer with sCMT and wIRA in combination with chemotherapy suggests that sCMT may enhance the effect
of chemotherapy. In a prior study on the treatment of patients with metastasised adenocarcinomas only 3/19 patients remained
in progression.
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