New dual inhibitors of EGFR and HER2 protein tyrosine kinases
Bioorganic & Medicinal Chemistry Letters（2006）
Abstract
A novel series of dual EGFR and HER2 inhibitors based on the pyrrolo[2,1-f][1,2,4]triazine nucleus is described. Biological evaluation in enzymatic and cell-based assays has identified a series of C-6 carbamates with potent biochemical and cellular activities.
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Key words
panHER,EGFR,Kinase inhibitor
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