Construction Of A Family Of Biphenyl Combinatorial Libraries: Structure-Activity Studies Utilizing Libraries Of Mixtures

Bernard R. Neustadt,Elizabeth M. Smith,Neil Lindo,Terry Nechuta,Alan Bronnenkant,Arthur Wu,Lydia Armstrong,Chandra Kumar

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1998）

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摘要

A set of biphenyl aminoacid building blocks has been synthesized. These were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this library as vitronectin receptor antagonists is described, together with SAR studies of the most active members. These studies illustrate several important features of combinatorial libraries. (C) 1998 Elsevier Science Ltd. All rights reserved.

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关键词

biphenyl combinatorial,libraries,mixtures,structure-activity

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