姜黄素对裸鼠乳腺移植瘤p21及CD44V6表达的影响
Chinese Journal of Pathophysiology（2007）
Abstract
目的:研究姜黄素对裸鼠乳腺移植瘤p21及CD44V6表达的影响.方法:选用人乳腺癌细胞株MCF-7对裸鼠进行异种移植,成瘤后随机分为2组:(1)阴性对照组;(2)姜黄素组.观测移植瘤的出瘤时间、成瘤率,测量瘤体大小并计算瘤表面积.同时应用RT-PCR,检测2组肿瘤组织中cyclin D1、p21及CD44V6的表达.结果:姜黄素组瘤表面积明显低于阴性对照组;姜黄素组p21表达量高于阴性对照组,CD44V6表达量明显降低,2组的cyclin D1表达差异无显著.结论:姜黄素抑制裸鼠MCF-7乳腺移植瘤CD44V6的表达,增加p21的表达.
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Key words
nude,Curcumin,Breast neoplasms,Cyclin D1,Mice
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