Ring-opening of chiral N-(3,4-dihydro-4-oxoquinazolin-3-yl)-substituted aziridines (Q∗-substituted aziridines): access to Q∗-free chirons

The presence of the quinazolin-4(3H)-one ring (Q*) in N-(Q*)-aziridines facilitates ring-opening by nucleophiles: removal of the Q* group from enantiopure ring-opened products gives useful chirons. (C) 1997 Elsevier Science Ltd. All rights reserved.